Overactivated autophagy contributes to steroid-induced avascular necrosis of the femoral head
نویسندگان
چکیده
منابع مشابه
Avascular Necrosis of the Femoral Head: Are Any Genes Involved?
Avascular necrosis of the femoral head (ANFH) is a pathologic process that results from interruption of blood supply to the femur bone resulting in the death of bone cells and collapse of the femoral head. Nontraumatic ANFH continuesto be a significant challenge to orthopedic surgeons. While the exact mechanisms remain elusive, many new insights have emerged from research in the last decade tha...
متن کاملApoptosis associated with Wnt/β-catenin pathway leads to steroid-induced avascular necrosis of femoral head
BACKGROUND The objective of the current study was to establish a rat model to investigate apoptosis in steroid-induced femoral head osteonecrosis occurring via the Wnt/β-catenin pathway. METHODS Male Sprague-Dawley (SD) rats were randomly divided into a control group (group A), model group (group B) and sFRP1 group (group C), each consisting of 24 rats, and the rats were intravenously injecte...
متن کاملA metabolomic study on early detection of steroid-induced avascular necrosis of the femoral head
The early and accurate diagnosis of steroid-induced avascular necrosis of the femoral head (SANFH) is appealing considering its irreversible progression and serious consequence for the patients. The purpose of this study was to investigate the metabolic change of SANFH for its early detection. Two stages were designed in this study, namely discovery and verification. Except the biochemical inde...
متن کاملCortisone-induced avascular necrosis of the femoral head.
Of ninety-five patients with corticosteroid-induced avascular necrosis of bone, ninety-one had involvement of the femoral head. The risk of developing this lesion appeared to be correlated with the total steroid dose. Forty-nine patients demonstrated a subchondral osteolytic defect which healed without proceeding to collapse. Four femoral heads in four patients developed sequestration, resembli...
متن کاملAvascular necrosis of the femoral head.
The patient was a 51-year-old man who was evaluated by a physical therapist for a chief complaint of right hip pain. The patient was treated with a single bout of nonthrust hip joint mobilizations, but due to the patient's atypical response and long-term use of oral corticosteroid medications, he was referred to his primary care physician. Radiographs and subsequent magnetic resonance imaging r...
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ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2017
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2017.4508